The brain is working as an interconnecting network. In several pathological conditions, there are alterations of the structural and/or functional connections. Revealing such data in vivo through advance diffusion and functional MRI methods hold promise for a better understanding and monitoring of several neurological disorders.
- to develop methods in animals in order to validate new directions pre-clinically (WP1-1)
- to develop robust methods of post-processing in animals (WP1-1) and humans (WP1-2)
- to set up first large scale studies in patients based on already available solutions (WP1-3).
- General objectives – To develop high-resolution MR acquisition sequences and implement advanced multimodal imaging analysis pipelines (including quality control) to build structural and functional macroscopic rodent brain connectomes.
- WP leaders – Sylvain Miraux (CRMSB) ; Laurent Petit, Marc Joliot (IMN)
- PhD candidate – Elise Consenza (supervisor: Laurent Petit)
- General objectives – to analyse the entire brain anatomy as a coherent whole and considering the relationships between tasks and anatomical levels.
- WP leaders – Pierrick Coupé, Boris Mansencal, Michaël Clément, Vinh-Thong Ta (LaBRI) ; Nicolas Papadakis (IMB) ; Gwenaelle Catheline (INCIA)
- PhD candidate – Edern Le Bot (supervisor: Pierrick Coupé)
- General objectives – To provide accurate and personalized symptom predictions (both functional and cognitive outcome) for any stroke location in the brain.
- WP leaders – Michel Thiebaut de Schotten (IMN) ; Thomas Tourdias, Aurélie Ruet (Magendie) ; Igor Sibon (INCIA)
- PhD candidate – Anna Matsulevits (supervisor: Thomas Tourdias)