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Find here all the news linked to RRI IMPACT (publications, seminars, events, AAP...)
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Scientific events
Conference - Mitochondrial psychobiology: foundation and emerging evidence of a mind-mitochondria connection, June 13, 10am, IBIO Conference Room
Symposium - Focus on Brain Energy Metabolism, July 17th & 18th, Domaine du Haut-Carré, Talence
We are pleased to invite you to the "Focus on Brain 🧠 Energy Metabolism" symposium, to be held on July 17–18, 2025, at the Domaine du Haut-Carré in Talence.
- Day 1 will focus on fundamental research 🔬, presenting the latest findings on metabolic interactions between different brain cell types, with particular attention to lactate exchanges – not only the astrocyte-neuron lactate shuttle, but also metabolic exchanges with microglia and oligodendrocytes.
- Day 2 will be dedicated to translational research 🩺, addressing the consequences of energy metabolism dysregulation in brain disorders, with a focus on preclinical and clinical research and roundtable discussions between scientists and clinicians.
A strong emphasis will be placed on young researchers, with multiple opportunities for oral and poster presentations. Prizes🏅will be awarded for the best contributions !
The event will take place in a friendly and welcoming atmosphere, including a wine 🍷 & cheese 🧀 poster session on the evening of Day 1.
📄 Full program: fbem.sciencesconf.org/resource/page/id/3
📅 Registration (deadline: June 15, 11:59 PM): fbem.sciencesconf.org/registration?lang=en
📣 Abstract submission (young researchers, dead-line June 15): fbem.sciencesconf.org/submission/submit?lang=en
We look forward to seeing many of you there !
Organizing Committee
- Anne-Karine Bouzier-Sore
- Aude Panatier
- Hélène Roumes
Distinction
Mireille Blanchard-Desce (ISM, RRI IMPACT), honored by the Achille Le Bel Prize 2024 from the SCF
RRI IMPACT congratulates Mireille Blanchard-Desce, member of RRI, CNRS research director at ISM, and winner of the Achille Le Bel 2024 prize awarded by the Société Chimique de France.
The prize is awarded by the SCF Board of Directors. It is awarded for internationally-recognized work that falls within the scope of the SCF's activities.
Mireille Blanchard-Desce entered the ENSJF in 1980, obtaining an agrégation in physical sciences and a doctorate in organic chemistry in 1989 (Université Pierre et Marie Curie) under the supervision of Jean-Marie Lehn. Mireille Blanchard-Desce has spent her entire professional career as a CNRS researcher since 198. At ENS Paris, she set up a young team to develop and optimize new chromophores for non-linear optics. During her thesis (under the supervision of Jean-Maire Lehn), she developed the first models of conductive molecular wires, then turned to the mechanisms of electron transfer in photosynthetic processes, which enabled her to direct her work towards molecular photonics and nanoscience. These studies led to the development of high-performance materials for electro-optical modulation.
In parallel with the covalent approach taken with organic nanodots, Mireille Blanchard-Desce was interested in an alternative route based on the self-assembly in water of multipolar, polarizable chromophoric motifs. Remarkably, this approach not only modulated optical properties (emission color, excitation response), but also surface properties (colloidal stability, interactions with cell membranes). In particular, these hyper-bright, modulable molecular nanoparticles have enabled two-photon microscopy angiography on small animals, tracking of individual nanoparticles in aqueous media, and two-color tracking within living cells.
Mireille Blanchard-Desce has been involved in research administration and management: unit director (UMR6510, Rennes) and team leader, elected for three terms to the CNRS Committee, coordinator and PI of two European ITN networks, numerous regional federative projects, member of the INC scientific council, among others. She plays an active role in the dissemination of knowledge through the supervision of over 30 theses and 20 post-doctoral fellows, teaching and publishing (editorial board of ChemPhysChem), expertise (ANR, LabEx, ERC, HCERES) and scientific mediation.
His work has been recognized by the CNRS, which awarded him the bronze medal in 1990 and the silver medal in 2008. She was awarded the Grand Prix Mergier-Bourdeix by the Académie des Sciences in 1999, the Palmes Académiques in 2009 and the Légion d'Honneur in 2012.
A member of the SCF, she has served on the board of the DCP and on the boards of the DCO and the French photo-physics, photochemistry and photo-sciences group.
To date, Mireille Blanchard-Desce's scientific output totals over 315 scientific articles, 1 book and 5 book chapters, 8 patents, 128 invited lectures at conferences and congresses, and around 100 seminars presented in academic and industrial settings.
Justine Couvez (ISM, LCPO, IMPACT), winner of the Mature your PhD + competition
LE RRI IMPACT congratulates Justine Couvez, doctoral student in the project and winner of the 2024 Mature Your PhD! competition. IMPACT félicite Justine Couvez, doctorante au sein du projet et lauréate du concours 2024 MAture Your PhD !
The Mature Your PhD+ competition is open to the entire Université de Bordeaux doctoral community in 2nd and 3rd year, including non-funded members. In addition to the Mature ton PhD program, which is open on a permanent basis, Mature you PhD+ is a way of recognizing your commitment. Co-constructed with the Graduate Research School and SATT AST, this is an annual competition (light pre-filing and pitch to a jury). For the 3 most convincing projects, you'll be awarded a 3-month fixed-term contract, during which you'll be able to devote yourself to this mission of innovation alongside your thesis work.
Call for projects
No call for the moment.
See you soon!
New publications
Publication - Bronchial wall T2w MRI signal as a new imaging biomarker of severe asthma by Benlala I, Dournes G, Girodet PO, Laurent F, Ben Hassen W, Baldacci F, De Senneville BD, Berger P. in Insights Imaging.
Abstract
Objectives: Severe asthma patients are prone to severe exacerbations with a need of hospital admission increasing the economic burden on healthcare systems. T2w lung MRI was found to be useful in the assessment of bronchial inflammation. The main goal of this study is to compare quantitative MRI T2 signal bronchial intensity between patients with severe and non-severe asthma.
Methods: This is an ancillary study of a prospective single-center study (NCT03089346). We assessed the mean T2 intensity MRI signal of the bronchial wall area (BrWall_T2-MIS) in 15 severe and 15 age and sex-matched non-severe asthmatic patients. They also have had pulmonary function tests (PFTs), fractional exhaled nitric oxide (FeNO) and blood eosinophils count (Eos). Comparisons between the two groups were performed using Student's t-test. Correlations were assessed using Pearson coefficients. Reproducibility was assessed using intraclass correlation coefficient and Bland-Altman analysis.
Results: BrWall_T2-MIS was higher in severe than in non-severe asthma patients (74 ± 12 vs 49 ± 14; respectively p < 0.001). BrWall_T2-MIS showed a moderate inverse correlation with PFTs in the whole cohort (r = -0.54, r = -0.44 for FEV1(%pred) and FEV1/FVC respectively, p ≤ 0.01) and in the severe asthma group (r = -0.53, r = -0.44 for FEV1(%pred) and FEV1/FVC respectively, p ≤ 0.01). Eos was moderately correlated with BrWall_T2-MIS in severe asthma group (r = 0.52, p = 0.047). Reproducibility was almost perfect with ICC = 0.99 and mean difference in Bland-Altman analysis of -0.15 [95% CI = -0.48-0.16].
Conclusion: Quantification of bronchial wall T2w signal intensity appears to be able to differentiate severe from non-severe asthma and correlates with obstructive PFTs' parameters and inflammatory markers in severe asthma.
Critical relevance statement: The development of non-ionizing imaging biomarkers could play an essential role in the management of patients with severe asthma in the current era of biological therapies.
Key points: Severe asthma exhibits severe exacerbations with a high burden on healthcare systems. T2w bronchial wall signal intensity is related to inflammatory biomarker in severe asthma. T2w MRI may represent a non-invasive tool to follow up severe asthma patients.
Keywords: Asthma; Inflammation; MRI.
Publication - Real-time multislice MR-thermometry of the prostate: Assessment of feasibility, accuracy and sources of biases in patients by Marcelin C, Crombé A, Jambon E, Robert G, Bladou F, Bour P, Faller T, Ozenne V, Grenier N, Quesson B. in Diagn Interv Imaging.
Abstract
Purpose: The primary purpose of this study was to evaluate the accuracy of an MR-thermometry sequence for monitoring prostate temperature. The secondary purposes were to analyze clinical and technical factors that may affect accuracy and testing the method in a realistic setting, with MR-guided Laser ablation on an ex vivo muscle sample.
Materials and methods: An ex vivo muscle sample was subjected to Laser ablation while using a two-dimensional multislice segmented echo planar imaging sequence for MR thermometry. The MR thermometry measurements were compared with invasive sensor temperature readings to assess accuracy. Subsequently, 56 men with a median age of 70 years (age range: 53-84 years) who underwent prostate MRI examinations at 1.5- (n = 27) or 3 T (n = 24) were prospectively included. For each patient, the proportion of 'noisy voxels' (i.e., those with a temporal standard deviation of temperature [SD(T)] > 2 °C) in the prostate was calculated. The impact of clinical and technical factors on the proportion of noisy voxels was also examined.
Results: MR-thermometry showed excellent correlation with invasive sensors during MR-guided Laser ablation on the ex vivo muscle sample. The median proportion of noisy voxels per patient in the entire cohort was 1 % (Q1, 0.2; Q3, 4.9; range: 0-90.4). No significant differences in median proportion of noisy voxels were observed between examinations performed at 1.5 T and those at 3 T (P = 0.89 before and after adjustment). No clinical or technical factors significantly influenced the proportion of noisy voxels.
Conclusion: Two-dimensional real time multislice MR-thermometry is feasible and accurate for monitoring prostate temperature in patients.
Keywords: MR-thermometry; Magnetic resonance imaging; Prostate; Prostate cancer; Thermal ablation.
Publication - Positive impact of sodium L-lactate supplementation on blood acid-base status in preterm newborns by Ibrahim, I., Perrot, C., Roumes, H. and al. in Pediatr Res.
Abstract
Background
Preclinical studies indicate that lactate is a crucial cerebral energy substrate, with Na-L-lactate administration significantly reducing brain lesion volumes and improving motor and cognitive functions following neonatal hypoxia-ischemia in rat pups. Its neuroprotective effects are linked to neuronal metabolic utilization, making it a promising candidate for treating newborns with hypoxia-ischemia encephalopathy, a condition where hypothermia remains the only established therapy. However, before initiating a clinical trial, it is necessary to assess the effects of Na-L-lactate infusion on blood parameters.
Methods
We retrospectively analyzed blood parameters in 60 premature neonates during their first days of life. Among them, 30 received Na-L-lactate instead of Na-Cl to prevent hyperchloremic acidosis. Blood pH, lactatemia, bicarbonates, glycemia, natremia, chloremia, base excess, and hemoglobin were monitored before, during, and after Na-L-lactate infusion.
Results
Our findings showed that Na-L-lactate infusion lowered blood lactate levels while increasing pH from 7.25 to 7.31. After stopping the infusion, lactatemia was 1.9 mM, and pH reached 7.32. Na-L-lactate supplementation effectively restored normal blood pH, maintained natremia, and prevented hyperchloremia. Notably, even in cases of high initial lactatemia, lactate levels decreased during the infusion.
Conclusion
Our data are promising and emphasize the need for further research to explore its potential applications in neonatal clinical care.
Impact
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Sodium L-lactate infusion does not increase blood lactate levels and restores normal pH in premature neonates.
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The study demonstrates that sodium L-lactate infusion avoids hyperchloremia while maintaining sodium levels, offering a potential alternative to sodium chloride.
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These findings highlight the need for additional research studies to further evaluate the safety, efficacy, and potential applications of sodium L-lactate infusion in neonatal care.