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Scientific events

Conférence - Imaging brain glucose metabolism, 28 septembre/14h, IBIO

Speaker: Christian Limberger, Université  fédérale Rio Grande del Sol de Porto Alegre, Brésil

Invited by Anne-Karine Bouzier-Sore

Date : jeudi 28 septembre / 14h00

Venue: IBIO, salle de conférence (RDC)

Vous pourrez également y assister via ce lien zoom


- Hervé Lemaître (

Journées nationales France Life Imaging (FLI), 11 et 12 décembre 2023, Bordeaux Amphi Broca - Carreire

France Life Imaging (FLI) et ses partenaires ont le plaisir de vous accueillir aux journées nationales regroupant tous les Réseaux d'Expertise, qui se tiendront les 11 et 12 décembre 2023 à Bordeaux.
Ces journées scientifiques répondent au double objectif :
• de faire émerger de nouvelles collaborations entre équipes françaises travaillant en imagerie médicale
• de faire un point sur les recherches menées en imagerie médicale et financés par FLI en France.
Durant ces journées scientifiques, vous pourrez suivre des présentations de projets financés par FLI autour des technologies émergentes dans différents laboratoires en France.
Puis en fin de journées, vous pourrez visiter les principaux équipements ouverts à la communauté scientifique, en imagerie clinique et préclinique, sur les sites de l'Institut de Bio-Imagerie et de l'IHU Liryc.
Anne Thevenoux (FLI)
Yannick Crémillieux (ISM)
Frédéric Lamare (INCIA)
Bruno Quesson (CRMSB)
Olivier Sandre (LCPO)
Emeline Ribot (CRMSB)

Call for projects

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See you soon !



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New publications

Publication - "Generating High-Resolution Synthetic CT from Lung MRI with Ultrashort Echo Times: Initial Evaluation in Cystic Fibrosis", Longuefosse A, Raoult J, Benlala I, Denis de Senneville B, Benkert T, Macey J,  Bui S, Berger P, Ferretti G, Gaubert J-Y, Liberge R, Hutt A, Morel B, Laurent F, Baldacci F, Dournes G, Radiology

Backgroung: Lung MRI with ultrashort echo times (UTEs) enables high-resolution and radiation-free morphologic imaging; however, its image quality is still lower than that of CT.

Purpose: To assess the image quality and clinical applicability of synthetic CT images generated from UTE MRI by a generative adversarial network (GAN).

Materials and Methods: This retrospective study included patients with cystic fibrosis (CF) who underwent both UTE MRI and CT on the same day at one of six institutions between January 2018 and December 2022. The two-dimensional GAN algorithm was trained using paired MRI and CT sections and tested, along with an external data set. Image quality was assessed quantitatively by measuring apparent contrast-to-noise ratio, apparent signal-to-noise ratio, and overall noise and qualitatively by using visual scores for features including artifacts. Two readers evaluated CF-related structural abnormalities and used them to determine clinical Bhalla scores.

Results: The training, test, and external data sets comprised 82 patients with CF (mean age, 21 years ± 11 [SD]; 42 male), 28 patients (mean age, 18 years ± 11; 16 male), and 46 patients (mean age, 20 years ± 11; 24 male), respectively. In the test data set, the contrast-to-noise ratio of synthetic CT images (median, 303 [IQR, 221–382]) was higher than that of UTE MRI scans (median, 9.3 [IQR, 6.6–35]; P < .001). The median signal-to-noise ratio was similar between synthetic and real CT (88 [IQR, 84–92] vs 88 [IQR, 86–91]; P = .96). Synthetic CT had a lower noise level than real CT (median score, 26 [IQR, 22–30] vs 42 [IQR, 32–50]; P < .001) and the lowest level of artifacts (median score, 0 [IQR, 0–0]; P < .001). The concordance between Bhalla scores for synthetic and real CT images was almost perfect (intraclass correlation coefficient, ≥0.92).

Conclusion: Synthetic CT images showed almost perfect concordance with real CT images for the depiction of CF-related pulmonary alterations and had better image quality than UTE MRI.

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Publication - "3D motion strategy for online volumetric thermometry using simultaneous multi-slice EPI at 1.5T: an evaluation study", by Ozenne V, Bour P, Denis de Senneville B & Quesson B, International Journal of Hyperthermia

Purpose: In presence of respiratory motion, temperature mapping is altered by in-plane and through-plane displacements between successive acquisitions together with periodic phase variations. Fast 2D Echo Planar Imaging (EPI) sequence can accommodate intra-scan motion, but limited volume coverage
and inter-scan motion remain a challenge during free-breathing acquisition since position offsets can arise between the different slices.
Method: To address this limitation, we evaluated a 2D simultaneous multi-slice EPI sequence with multiband (MB) acceleration during radiofrequency ablation on a mobile gel and in the liver of a vol-unteer (no heating). The sequence was evaluated in terms of resulting inter-scan motion, temperature uncertainty and elevation, potential false-positive heating and repeatability. Lastly, to account for potential through-plane motion, a 3D motion compensation pipeline was implemented and evaluated.

Results: In-plane motion was compensated whatever the MB factor and temperature distribution was found in agreement during both the heating and cooling periods. No obvious false-positive temperature was observed under the conditions being investigated. Repeatability of measurements results in a 95% uncertainty below 2 C for MB1 and MB2. Uncertainty up to 4.5 C was reported with MB3 together with the presence of aliasing artifacts. Lastly, fast simultaneous multi-slice EPI combined with 3D motion compensation reduce residual out-of-plane motion.

Conclusion: Volumetric temperature imaging (12 slices/700 ms) could be performed with 2 C accuracy or less, and offer tradeoffs in acquisition time or volume coverage. Such a strategy is expected to increase procedure safety by monitoring large volumes more rapidly for MR-guided thermotherapy on mobile organs.

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Publication - "Atlasing white matter and grey matter joint contributions to resting-state networks in the human brain" by Nozais V, Forkel SJ, Petit L. & al., Commun Biol

Over the past two decades, the study of resting-state functional magnetic resonance imaging has revealed that functional connectivity within and between networks is linked to cognitive states and pathologies. However, the white matter connections supporting this connectivity remain only partially described. We developed a method to jointly map the white and grey matter contributing to each resting-state network (RSN). Using the Human Connectome Project, we generated an atlas of 30 RSNs. The method also highlighted the overlap between networks, which revealed that most of the brain’s white matter (89%) is shared between multiple RSNs, with 16% shared by at least 7 RSNs. These overlaps, especially the existence of regions shared by numerous networks, suggest that white matter lesions in these areas might strongly impact the communication within networks. We provide an atlas and an open-source software to explore the joint contribution of white and grey matter to RSNs and facilitate the study of the impact of white matter damage to these networks. In a first application of the software with clinical data, we were able to link stroke patients and impacted RSNs, showing that their symptoms aligned well with the estimated functions of the networks.

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Publication - "Lifespan Neurodegeneration Of The Human Brain In Multiple Sclerosis", by Coupé P, Planche V, Mansencal B, Kamroui RA, Koubiyr I, Manjon JV, Tourdias T, bioRxiv [Preprint]

Background: Atrophy related to Multiple Sclerosis (MS) has been found at the early stages of the disease. However, the archetype dynamic trajectories of the neurodegenerative process, even prior to clinical diagnosis, remain unknown.

Methods: We modeled the volumetric trajectories of brain structures across the entire lifespan using 40944 subjects (38295 healthy controls and 2649 MS patients). Then, we estimated the chronological progression of MS by assessing the divergence of lifespan trajectories between normal brain charts and MS brain charts.

Results: Chronologically, the first affected structure was the thalamus, then the putamen and the pallidum (3 years later), followed by the ventral diencephalon (7 years after thalamus) and finally the brainstem (9 years after thalamus). To a lesser extent, the anterior cingulate gyrus, insular cortex, occipital pole, caudate and hippocampus were impacted. Finally, the precuneus and accumbens nuclei exhibited a limited atrophy pattern.

Conclusion: Subcortical atrophy was more pronounced than cortical atrophy. The thalamus was the most impacted structure with a very early divergence in life. It paves the way toward utilization of these lifespan models for future preclinical/prodromal prognosis and monitoring of MS.

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Publication - "Deep grading for MRI-based differential diagnosis of Alzheimer’s disease and Frontotemporal dementia", by Huy-Dung Nguyen, Michaël Clément, Vincent Planche, Boris Mansencal and Pierrick Coupé, Artificial Intelligence in Medicine

Alzheimer’s disease and Frontotemporal dementia are common forms of neurodegenerative dementia. Behavioral alterations and cognitive impairments are found in the clinical courses of both diseases, and their differential diagnosis can sometimes pose challenges for physicians. Therefore, an accurate tool dedicated to this diagnostic challenge can be valuable in clinical practice. However, current structural imaging methods mainly focus on the detection of each disease but rarely on their differential diagnosis. In this paper, we propose a deep learning-based approach for both disease detection and differential diagnosis. We suggest utilizing two types of biomarkers for this application: structure grading and structure atrophy. First, we propose to train a large ensemble of 3D U-Nets to locally determine the anatomical patterns of healthy people, patients with Alzheimer’s disease and patients with Frontotemporal dementia using structural MRI as input. The output of the ensemble is a 2-channel disease’s coordinate map, which can be transformed into a 3D grading map that is easily interpretable for clinicians. This 2-channel disease’s coordinate map is coupled with a multi-layer perceptron classifier for different classification tasks. Second, we propose to combine our deep learning framework with a traditional machine learning strategy based on volume to improve the model discriminative capacity and robustness. After both cross-validation and external validation, our experiments, based on 3319 MRIs, demonstrated that our method produces competitive results compared to state-of-the-art methods for both disease detection and differential diagnosis.

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