ARNA Seminar Series - Dr Fabrice Caudron (IGMM, Montpellier)

Dr Fabrice Caudron présentera une conférence intitulée "Whi3 Condensation and RNA Regulation: A Molecular Switch for Yeast Deceptive Courtship Memory".

Abstract

Prions and prion-like proteins are master regulators of cellular memory and stress adaptation, driving critical decisions such as cell cycle entry. In Saccharomyces cerevisiae, the prion-like protein Whi3 acts as a molecular switch: its condensation encodes the memory of deceptive courtship, enabling cells to bypass G1-phase arrest and restart division. But how does Whi3 sense and integrate signals? What
triggers its condensation, and is Whi3 alone in this role? In this seminar, I will present our efforts to reconstitute Whi3 condensation in vitro, and discuss how Whi3’s conformational change triggers a functional switch—shifting from repressing CLN3 mRNA translation in its soluble state to enabling cell cycle progression upon condensation. I will show how Whi3 integrates the biophysical state of the plasma membrane to form condensates and will explore how Whi3 and other prion-like proteins assemble into a regulatory network, orchestrating the pivotal decision of cell cycle entry.

Contact

• Erice Cornes, eric.cornes@inserm.fr