Paola Luciani présentera une conférence intitulée "Patient-centric lipid-based therapeutic approaches to tackle inflammation and fibrosis".
Abstract
The treatment of fibrosis and inflammation remains challenging due to their complex nature, requiring localized and sustained interventions. Our group has developed lipid-based and 3D-printed drug delivery systems tailored for conditions such as osteoarthritis, ulcerative colitis, peritoneal disease, endometriosis, and recurrent urinary tract infections. Using liposomes and lipid mesophases, we created long-acting injectables, temperature-triggered gels, and self-emulsifying oral printlets to enhance drug solubility, retention, and antifibrotic activity. In women’s health, we designed mucoadhesive ovules and stents for sustained local therapy. Across models, these technologies improved therapeutic efficacy while minimizing systemic side effects. Collectively, our work demonstrates how lipid and additive manufacturing platforms can transform localized treatment strategies in reproductive, gastrointestinal, musculoskeletal, and hepatic diseases, with strong translational potential.
Contact
- Jeanne Leblond Chain, jeanne.leblond-chain@inserm.fr
Flyer Séminaire Pr. Paola Luciani
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