ARNA Seminar Series - Pr. Jessica Rouge (University of Connecticut, USA)

Le Pr. Jessica Rouge est l'invitée de Philippe Barthélémy. Elle présentera sa conférence intitulée "Overcoming nature's barriers: enhancing endosomal escape and the therapeutic efficacy of nucleic acids using DNA surfactant conjugates" à l'amphithéâtre du BBS sur le campus Carreire.

Abstract

Our laboratory has worked to develop formulations for delivering therapeutic nucleic acids taht can stabilize, target, and control the release of DNA and RNA molecules into cells. A major obstacles in nucleic acid therapeutic is the ability to successfully deliver these biomolecules to the cytosol. Overcoming the lipid membrane barriers of cells and endosomes is the major bottleneck to this process. We are thus designed the chemistry of our formulations to oufit nucleic acids with the ability to destabilize membrane barriers while also presentating targeting ligants and degradation machanisms taht can help control trajectory of nucleic acid cargo once inside a cell. In this talk, I will summarize our latest advancements in delivery nucleic acid cargo, both short therapeutic oligonucleotides and larger molecules such as mRNA.

Contact

• Philippe Barthélémy
• Axel Innis