Le 27 mars prochain, le Dr Bastien Venzac (LAAS, Toulouse) est l'invité du Pr Matthieu Raoux et du CBMN.
Il présentera sa conférence "3D Printing for In Vitro Models of Extracellular Matrices and Microfluidics".
Abstract
Light-based 3D-printing is more and more employed in the field of microfluidics, organ-on-chip and microphysiological systems. I will first present the use of stereolithography for the fabrication of 3D microfluidics systems, and focus on the addition of functionalities allowed by the integration of external objects inside prints: imaging windows, valves, porous membranes, some of them being of high interest for the fabrication of organ-on-chip systems. In a second part, I will present the use of high resolution, two-photon 3D printing for the creation of models of extracellular matrices (ECM). Our objective is to create fibrillar scaffolds with fibers having the same dimensions and stiffness as collagen fibers, the main constituent of the ECM, and to tune the scaffold stiffness by the fiber organization and design. We are then studying the impact of the model micro-architecture and mechanics on fibroblast activation, in the context of the Crohn Disease.
Contact
- Matthieu Raoux, matthieu.raoux@u-bordeaux.fr