Bouzier-Sore Anne-Karine
Career
Anne-Karine Bouzier-Sore is a biochemist and biophysicist working in the field of brain metabolism. She is studying the metabolic interactions between astrocytes and neurons and in particular the importance of the astrocyte-neuron lactate shuttle (ANLS) to support brain functions. She mainly takes advantage of NMR spectroscopy (MRS) as well as MRI for her explorations. Using 13C-labeled substrates, she demonstrated that lactate is a preferential oxidative substrate for neurons over glucose. Recently, using functional MRS and MRI, she confirmed the importance of astrocytic lactate to support brain activity in vivo.
Her team is also working on the neuroprotection of neonatal hypoxia-ischemia (NHI) and she demonstrated that lactate administration is able to reduce brain lesions and rescue motor and cognitive deficits linked to NHI. Her team has also a strong interest in the impact of nutrition on brain metabolism, and has shown that polyphenols can also be neuroprotective in a NHI context, in particular through an upregulation of genes linked to the ANLS.
